An antidote for Staphylococcus aureus pneumonia?
نویسندگان
چکیده
منابع مشابه
An antidote for Staphylococcus aureus pneumonia?
Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial infections in the United States. Severe invasive MRSA infections, which include pneumonia, are difficult to treat because the bacteria are resistant to antibiotics. A new report now shows that immunization against alpha-hemolysin (Hla), a cytolytic toxin secreted by most S. aureus strains, protects mice against...
متن کاملVaccination against Staphylococcus aureus pneumonia.
BACKGROUND Staphylococcus aureus causes serious infections in both hospital and community settings. Attempts have been made to prevent human infection through vaccination against bacterial cell-surface antigens; thus far all have failed. Here we show that superantigens and cytolysins, when used in vaccine cocktails, provide protection from S. aureus USA100-USA400 intrapulmonary challenge. MET...
متن کاملLethal Necrotizing Pneumonia Caused by an ST398 Staphylococcus aureus Strain
To the Editor: Several recent studies have shown massive colonization of livestock (especially pigs) and livestock workers by methicillin-resistant Staphylococcus aureus (MRSA) in western Europe, Canada, and the United States (1,2). Livestock MRSA isolates belong almost exclusively to a single sequence type, ST398. Evidence of zoonotic and interhuman transmission of methicillin-resistant and me...
متن کاملMethicillin-resistant Staphylococcus aureus nosocomial pneumonia.
Affi liations: From the Division of Clinical Science, St. George’s University of London. Financial/nonfi nancial disclosures: The author has reported to CHEST the following confl icts of interest: Dr Jones has received consulting fees and speakers honoraria from GlaxoSmithKline. Correspondence to: Paul W. Jones, PhD, Division of Clinical Science, St. George’s University of London, Cranmer Terr,...
متن کاملVaccine protection against Staphylococcus aureus pneumonia
Staphylococcus aureus pneumonia causes significant mortality in hospitalized or healthy individuals, and recent increases in morbidity are attributed to the rapid spread of methicillin-resistant S. aureus (MRSA) strains, which are often not susceptible to antibiotic therapy. Alpha-hemolysin (Hla), a secreted pore-forming toxin, is an essential virulence factor of MRSA in a mouse model of S. aur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2008
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20080167021208c